Undermethylation supplements reddit. Some people more slowly recalibrate to higher .
Undermethylation supplements reddit . I am also a fan of adding extra vitamin C. I take a high dose methyfolate supplement everyday which supplies 8500mcg of folate. it's best to seek advice from the pharmacist on duty. Given that acetyl-CoA is an essential nutrient for both the citric acid cycle and the acylation of choline into acetylcholine; and that acetate can improve symptoms of depression it seems probable this is partially relevant at least. Taken with your folate supplement, B9, and really Bs in general, is recommended for better health. It is available over the counter. This a form of Vitamin B12; a deficiency can lead to low energy levels, poor concentration, sluggish thinking and anaemia. Your significant other may be a crazy whack job on occasion, but that alone doesn’t mean they need to be downing buttloads of methyl donors for the A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Another thing I tried was taking a beef kidney supplement DAO enzyme for several months (Ancestral Supplements brand), but didn't find that it made a difference. Does a B12 deficiency mean you have to be under methylated, or could you still be overmethylated? Supplement ~3-5g/day of creatine monohydrate or creatine hydrochloride (HCL). Most people aren’t fans of taking pharmaceutical medications once they have pinpointed the problem of undermethylation. No actually because 95% of them do not have the right forms or doses. if you are too sensitive to most methylation support supplements), consider B Complex MF. Which supplements should I take? Would TMG (or SAM-e) plus a methylated B Complex be enough for undermethylation issues? Are MSM, carnosine/beta alanine and sunflower lecithin good for undermethylation and high histamine and homocysteine? I suspect I have also slow COMT. nasal passage congestion due to tissue swelling, NOT due to mucous) significantly decreases not long after take the b6 supplement. The causes of undermethylation are typically a combination of the following: Protein deficiency (undermethylators do not do well on low animal protein diets such as vegan and vegetarian) Undermethylation is most commonly treated with supplements that assist with methylation, including methylfolate and vitamin B12. April 20, 2024 Personally, I don’t buy into the over/undermethylation as a whole. The research though is still Lin early stages. Short background: 48 yrs old male. try non-drowsy antihistamines and (topical) nasal decongestants which can easily be bought OTC at retail pharmacies. This is on top of a whole foods plant based diet, rich in folate. You should look at all your symptoms to find out if you are over- or under-methylated. It's an H1 antihistamine, though I've never found it at all sedating. Good luck getting stronger and glad to hear you found a supplement that makes a difference! I discovered TMG(Trimethylglycine) and i'm using it for about 1 month, it's improves my energy and mood immensely and last a lot longer than b12, the reason i started it was the effects of this supplements regarding methyl groups in the body and how it's supposed to help anyone with this condition, so far it's working very well. 2 supplements: for the 3 days of sulfite containing foods follow the MTHFR cycle supplements:example (help with Methylation and transufation) Methylfolate L-5-MTHF 60 caps take 1 per day. Undermethylation is also associated with a range of Supplements for undermethylation Hill Calcium Magnesium methionine Omega-3 fatty acids B12 vitamin Vitamin C Results of taking medications Antihistamines: Since patients with undermethylation tend to have high histamine levels, the use of an antihistamine may result in favorable effects. Hi Braingains22, I share some of the mutations (C677T etc. If you want to stay plant based look for plant based milks with I’ve been taking this supplement daily without fail for probably 4 or 5 years now. I’ve started using this liquid sunflower lecithin supplement so I can microdose choline. A lot of girls on reddit buy their skin products like retinol from that company. I suspected b6 due to the tingling and testing confirmed my levels were too high. You also need to not eat foods high in cadmium and arsenic like chocolate and rice to not cause a inhibition of the enzyme CYP27A1. I've seen the usual list of things to do to manage my Slow COMT genes: Limiting caffeine and alcohol consumption Seeking advice on which supplements to stop taking or add based on genetic genie methylation&detox results (much appreciated!) upvotes · comments r/MTHFR She may use diet, supplements, lifestyle changes or medication to treat your illness but will seek the most gentle way to help your body restore balance along with the least invasive treatment possible. Internet Culture (Viral) You might stop experimenting on your body with supplements until you get more factual information from your gene variant test and the results from what blood tests the gene variants indicate you Supplement L-methylfolate and B12. In the future, try Flonase. The B2 I was originally using was 400mg/day but I am currently trying out 100mg/day. Current symptoms: High Discussion on the relative pros and cons for supplementation are accepted and encouraged. A number of people have stated that taking a relatively high dose of the nutrient for a prolonged period has resulted in a cessation of Been saying this for good, and questioning people, some of who take around 5 gram of choline from their daily lipo supplements, but no one could provide answer to my concern, and a supplement company here on reddit said there isn’t enough research about this topic and/or (forgot) whether or not all that choline would be converted to TMAO . e. Most of the effects people feel are cardiovascular in nature, not a topic of methylation Can the start of methylation cause anhedonia, apathy, depression and more cognitive dysfunction as well as restlessness? I thought that it was symptoms of overmethylation, and not undermethylation. The list When you squeeze you should feel a “funny bone tingle”. The GAPS diet can be helpful for optimising gut bacteria. I also used to have low motivation, brain fog and depression, and I know that if I take that much B12 (5000mcg) and methylfolate (800mcg) it would be too much and it A few things. Otherwise try to get B12 from non-supplement forms. If you start with high histamine and you take too many methylated vitamins and or methyl donor supplements you are likely to get a high histamine/over methylation symptoms reaction. I don't think of Reddit as social That doesn’t mean that you shouldn’t take niacin; I personally trend toward undermethylation but I still take it, and it does in fact give me an immediate sense of motivation. Or check it out in the app stores As a big adept of supplements (thankfully) i only took 1/10 of a tablet from life extention for what was supposed to be a taste (170mcg off of 1. Vitamin D uses magnesium to be converted in the body, and most of Asked chatgpt: For someone with fast COMT activity, here are three supplements that may help support dopamine levels: L-Tyrosine : This amino acid is a precursor to dopamine and can help support its production, especially in individuals with fast COMT activity. Intestinal Dysbiosis Intestinal Health A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Although undermethylation is more common with the MTHFR gene, overmethylation may instead be the Since I've delved into the topic of MTHFR / L-metyhlfolate supplements, I've often heard something along these lines: You should avoid being "overmethylated", it will make you too euphoric Niacin will cause you to become "undermethylated", that A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Undermethylation is idiosyncratic and needs a lot of experimenting to get right. Basic Description: The term “overmethylation” describes the experience of negative side effects generated from an increase in methylation-related nutrients. homocysteine builds up, lack of methionine, There are certain supplements that deplete methyl groups and TMG helps add those back. ” It’s a pretty good-standard guide for navigating Abstract: Vitamin B2 (Riboflavin) supplementation might be a potential solution for “overmethylation” . Another thing that can contribute to Supplement with: Methionine Methionine is an amino acid precursor to SAM-e. Copper to Zinc ratio may be a bit high for most these daily vitamins. i don't really find time to take it a lot because someone on reddit said something about it messing with blood sugar and turning test subjects pre-diabetic (didn't bother reading the study tbh) - so i only take it at minimum 2 hours after eating and minimum 2 hours before - because allegedly then it doesn't mess as Symptoms of undermethylation should improve if you follow my recommendations for methylation support below. Or check it out in the app stores A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. B complex supplements usually have B6 and B9 levels below the Tolerable Upper Intake, so you're probably safe there. The only vitamins I currently supplement are B2 and B9. If this is the case, should I get a methylated or standard B Complex? I always knew i had something wrong with me and spent thousands $$ and wasted years trying to find out, had an arsenal of supplements but after the tmg experience, this is the main supplememt for me that is not a supplement but more essential, i get it in bulk now :). . I also take a B complex that provides 400mcg of folate. MTHFR mutation (heterozygous C677T) + slow COMT (homozygous Met/Met) supplement protocol Question Many of the supplement makers were calling it a hang over cure. That leads me to think my symptoms are more tyramine related than histamine. I'm sorry you're going through this and I'm glad you're doing better. so copper supplements may exacerbate symptoms, while zinc Try one a day in the am. ADHD is characterised by low dopamine and oxidative stress and there are some underlying biochemical factors that greatly contribute to this: 1/ Methylation imbalancer - Undermethylation causes low serotonin and dopamine I find this overmethylation vs undermethylation complicated. Many fish oil brands on our shelves are rancid and of little help. Filed Under: Treatments, Uncategorized, undermethylation Undermethylation has been implicated in various diseases, autoimmune conditions, cancer etc. If you’re wanting to gently optimize your methylation (e. What I would do: If you haven't been supplementing you could do fairly routine bloodwork to see if it reveals anything: Iron panel, vitamin D (often low in B12D patients), serum B12 Thank goodness for reddit! I had been feeling suicidal after taking phosphadityl choline in a large dose for several weeks. however, do note that topical nasal decongestants shouldn't be used for five to seven consecutive days as it can cause rebound nasal congestion. I did a spin class 2 months ago and left calf was a bit Waking up suddenly from adrenaline rushes is a low cortisol symptom exclusively. Technically, I do use non-fortified nutritional yeast, which has some B vitamins, but isn't really a supplement per se. I had some good responses I would say the most essential supplements are: Probiotics are a very common supplement that you can find in the vitamin aisle at your local grocery store. The 5mg Folate supplement I found is by Now foods - which should be available globally. Members Online • Bigpoppapenguin123 . The FDA does not regulate supplements as drugs, which means companies don't have to submit proof of safety and effectiveness for a specific use, but the FDA is interested in knowing if a supplement is making you sick. † B Complex MF was created by Dr. Do you peeps supplement anything like I would love to use these supplements but my problem is my stomach walls are worn down and too many pills make me nauseous af and I have some other weird symptoms like swallowing air when I sleep causing me to burp and be nausious ontop of the gastritis I already have, the doctors couldnt really figure this one out he just said it could be So take folate supplements, right? That’s personally what I do. Just add a K2 supplement as it is missing entirely, and an additional magnesium supplement. The risk you run is having too many methyl groups i. It also depends on a person's beginning whole blood histamine level. Fish oil is another common supplement that has been proven to improve brain function, mood, and cardiovascular A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Carlson Cod Liver Oil is good, AOR advanced B complex is good to. However, discussions or rants declaring a supplement or supplement regimen useless based From what I've understood, usually an undermethylator has low dopamine and serotonin, thus he could boost methylation and the production of neurotransmitters by supplementing B vitamins Undermethylators are one of the primary subtypes described by the Walsh Protocol. I understand we are on a supplement subreddit. Undermethylation & Histamine. But this made me feel like trash, which could be its fault or something else entirely. Creatine production uses up 40-45% of SAM, the main methylation output. If that still causes issues look for a multi with the "lessor" form cyanocobalamin as it will remove some methyl groups to process it. It would show up on the checkout counter at 7-11 next to 5 hour energy drinks and weight loss pills. Methyl B12 is Dangerous for some people! The reason why Methyl B12 is causing these strange effects (anxiety, feeling of doom, shortness of breath, palpitations and high blood pressure) is plain and simple. Manganese, copper, DMAE and choline may also worsen depression symptoms and thus should also be avoided in Sure, the supplement that has made me feel far more mentally clear has been PCOSITOL by Delfran It has methylfolate and Methylcobalmin as well as inositol in the right ratio. So I'd look for the supplement that has the most of everything else relative to the B3. 1. Internet Culture (Viral) Amazing; Animals & Pets the variants for the disease and the deficiencies then it is The supplements I mentioned are cheap, so it’s a perfectly fine stack for long term use. g. ; SAM-e SAMe (s-adenosyl methionine) is a naturally occurring amino acid manufactured from methionine, which is found in protein-rich foods, and produced by the liver. Before you spend money on a shooting at the wall approach to supplements, consider getting some blood tests. Look up symtoms for overmethylation and undermethylation. Some supplements are toxic to the body, who knows what fillers and heavy metal toxins are present in these Hello there! This community serves a location to share material and thoughts related to solving "overmethylation". You should otherwise be fine with normal B12 supplements. I have symptoms from both OVER and UNDER, and when I read the symptoms of each I recognize my symptoms. I did test high for b12 at one point but mostly my blood work has been good. Even 100% natural, non-synthetic supplements like a vitamin B complex of tulsi, lemon and guava that I am currently taking. Undermethylation can cause deficient choline. It won’t take long. Yes, exactly right. Reply reply. You can be overmethylating one neurotransmitter sure. 7 mg) no genetic testing where i'm from but i have all the symptoms of undermethylation A cheaper alternative is centrum silver 50+, which has most of what you need. Just started taking a b6 supplement, and noticed that my nasal swelling congestion (i. I've been getting a headache whenever I take over 1g of Niacinamide. true. I see supplementing choline recommended as a way of supporting methylation but no defacto way of doing it. But if you are dealing with motivation problems, addiction, low mood and anger issues (extremely unlikely that comes from only 500 mg of Tyrosine), I really need to say that therapy should maybe be the first avenue to explore together with maybe getting blood work done to get a proper idea about That depends on all of a person's own individual gene variants. By taking multiple methyl donors, you can target different aspects of methylation and increase the chances of achieving optimal methylation. Abstract: In the following sections I explain why lithium orotate may help prevent "overmethylation" side effects caused by relevant nutrients such as folate, B12, choline, etc. Carnivores, for Need your advice on how best to go about tackling my issues that have plagued almost ALL my adult life. Also, reading a lot about overmethylation vs undermethylation helped a lot. They're good for your digestive system and help boost your immune system. Sam-e makes me feel so lazy and poor stress tolerance. I quit all the supplements and taking now vitamin D3 because my levels are 32 and i life up north, last week my homocysteine was 9. Yet many B complex supplements exceed the Tolerable Upper Intake in one dosage. I recommend adding a zinc supplement of your choice. I've heard that 90% of ocd cases are from I had all of your symptoms from b6 toxicity. Foods and supplements high in retinol/carotenoids,vitamin B6 and seed oil are for me the most problematics and the things you need to avoid at all cost as all three convert inevitably into toxic aldehydes. (BHMT patway) Phosphatidylcholine is formed by methylation. Hi all, I got a blood test for a methylation profile and I am awaiting the results on this. It actually does work in that context however the FDA and groups thought it was contributing to binge drinking. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Recent bloodworks showed high Over methylation is very uncommon. It boosts methylation William Walsh, Nutrient Power (New York, NY: Skyhorse Pub. Have been taking 1000 mcg supplements 1-2x daily since then, recently 1x a day. Or check it out in the app stores TOPICS. Or check it out in the app stores Seems one has to do with undermethylation and the other has to do with overmethylation. Supplements should just be there to fill in the gaps or for specific purposes. Question about Go to Supplements r/Supplements • by PATHAN-ZONDRA. No matter what I've tried for the last 10 years (not consistently, in phases), vitamin supplements always make me feel worse. Many things can be tolerated by healthy people but not well tolerated by some conditions. and overmethylation vs. If you know for a fact that undermethylation is the problem, Get the Reddit app Scan this QR code to download the app now. I would feel so horrible after a hard workout and a 50g protein meal (specially of whey). I should add that the Genesite test stated: Homozygous T Allele of C677T Polymorphism, Significantly Reduced Folic Acid Metabolism, Significantly Decreased Serum Folate Levels, and Significantly Increased Homocysteine Levels. Ben Lynch to address the need for a We would like to show you a description here but the site won’t allow us. Folic acid can be bad for people yes, generally through supplements as when naturally occurring in foods it seems safer. It’s very complex. I chose two methyl donors: methionine, and TMG. After 3 years of chasing histamine, genetics, and finally realizing i was having overmethylation and LOW histamine , with histamine producing gut infection Citrobacter and proteus, which complicates it future, I did niacin and I felt better but then tried collagen, NOT pure glycine, which is not found pure in nature, but collagen, which is , is However after using NMN at 1g per day for 4-5 days in a row I started to get symptoms of "undermethylation" where I basically just felt extreme fatigue and could barely get out of bed so I decided I needed to increase methylation, but this time decided to try TMG instead Sorry I’m new to Reddit and don’t know how to link other posts (if others read this and know the post I’m talking about, pls link it), but search “MTHFR: A Supplement Stack Approach. I want it lower. If you've tried Nasocort, and it didn't help much, I'd suggest trying Nasonex instead. I tested high in homocysteine - 12. be used only when there is an issue with its methylation (MTR gene SNP). Some people are naturally overmethylators which might benefit from taking a few things that reduce methylation. Some people genetically have overmethylation or undermethylation so B12 and folate can tip What is the smallest amount of supplements I could take to treat undermethylated schizophrenia naturally? But don’t buy it in bulk (more than 2-3 months worth at a time) because the capsules or tablets both seem to react to moisture over time (even with the packets inside the bottle to help). Social isolation: Some individuals with undermethylation may isolate themselves from others and prefer to be left alone, especially during the completion of work. The human body is very complex. About a year ago I got deathly ill from the Covid vaccine (possibly had Covid at the same time) and as I slowly recovered I noticed my libido was gone. I make sure to do a lot of research before taking a new supplement. Or check it out in the app stores Ben Lynch developed a couple of supplements targeted at histamine. i also read somewhere that cut onions can help with clearing the nasal 14 votes, 27 comments. Unbalanced diets as well. Since undermethylation results in low levels of calcium, magnesium, methionine, and Vitamin B6 – it’s important to consider these for supplementation. View community ranking In the Top 10% of largest communities on Reddit. Brainfog, losing your train of thought, spacing out and losing things are all related to the executive functioning of your brain. High homocysteine Get the Reddit app Scan this QR code to download the app now. Choline Calcium Magnesium Methylfolate and methylb12 make me feel awful if I don’t supplement with creatine. If you have the MTHFR mutation, homozygous, as heterozygous is not an issue, or have low folate levels you definitely should supplement with B2 as it is very important for flavoenzymes What did you expect them to do, go to a supplement Reddit sub, start researching anecdotal bro science and prescribe you a b complex? They didn’t do that because that doesn’t work Reply reply Google overmethylation and undermethylation. I'm hoping TMG can prevent this. You'll also likely benefit from reducing histamine in your diet. Supplementing SAM when undermethylated helps make up for the deficit and so may be useful, but once methylation is normalized, then supplementing SAM may lead to overmethylation side effects. Only my second day on a methylfolate supplement (800mcg + B12) and I started to experience the famous jitters of folate Daily 10mg elemental Lithium (2x ~120mg Orotate supplements, edit: note Lithium Orotate delivers ~5mg lithium per 120mg of Orotate compound pill powder, the front label will say 5mg or around 120mg) with a B-Vitamin complex is a measurable improvement in overall mood and cognition. So, supplementing creatine unburdens the methylation cycle from having to produce all or most of that creatine, and therefore frees up SAM for other uses, such as neurotransmitter production and breakdown. At some point you just have to accept that no matter what the genetic test says, your body has the final say. 112 votes, 168 comments. I have many symptoms of undermethylation (mainly anxiety, overthinking, brain fog, some repetitive behaviors, disturbed sleep due to high REM). I discovered I have an undermethylation problem I started taking NR from Truniagen irc and after a couple of pills 300mg each in a span of 4-5 days I started seeing my fatigue getting worse coupled with my attention deficit. That said, I recommend the capsules because the tablets hurt when swallowed after they start losing their form over time. They generally exhibit seasonal allergies, perfectionism, competitiveness, and other distinctive symptoms and traits. This is because high histamine levels and undermethylation are associated. This is a pearl on reddit! I search for something like this for so long! Impressive work! Question: Blood checks ramping up creatine and glycine takes time. He talks about them at the bottom of this page: Common undermethylation symptoms include: migranes, allergies, sleep disruption, mood dysregulation, memory problems A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. as well as doing more research on undermethylation. This state can result from a variety of supplements (e. In terms of digestion support you could consider digestive enzymes and/or ginger. Again, I'd focus on diet, using an app like Cronometer, to make sure that you are getting good coverage of all your vitamin and mineral needs. Adding a boron supplement can increase absorption Get the Reddit app Scan this QR code to download the app now. for discussion of illicit and illegal compounds. Under methylation supplement stack . Life Extention or Seeking health have good trace minerals supplements. Now, why am I no longer able to take these The only supplement I know that can help with cognition is omega 3 oil, but never min that, see a doctor. I would split your Minerals and Vitamins up into a few supplements to get proper dosing and forms. B6 is water-soluble so the assumption is that it's non-toxic but it can mess up your body if taken in such huge amounts. Abstract: Vitamin B2 (Riboflavin) supplementation might be a potential solution for “overmethylation” . I think of it as my “cross things off my to-do list” supplement! It’s just more important for you to go slowly, not much higher than your threshold for flushing. Feeling good after taking methylfolate does not indicate undermethylation. In fact, most threads sharing things like: - decaf increasing anxiety despite no meaningful caffeine content | -high does caffeine pills producing calm energy, while 1/3rd the caffeine from coffee causing irritability and shitty feelings, etc don't really get answered by the COMT phenomenon and this goes either unexplained or attributed to MAOI Causes of Undermethylation. And while I don’t subscribe to the entire worldview of Yasko, Lynch (who makes very good supplements BTW), and others in it’s entirety, there is quite a bit of good science to be had there. Also, I took the 7 mg methylfolate yesterday (6S) and I feel god awful today. Vitamin A came up, and turns out it works! Taking supplements that boost s-adenosylmethionine levels ("methylation supplements") can cause many kinds of negative symptoms depending on your body, but the main point is that too much SAM can be a bad thing, one way or another. You can read up on overmethylation and undermethylation. Riboflavin kept supporting the methylation process till I began to be able to tolerate methyl Apparently Niacinamide causes undermethylation and raises histamine and homocysteine. These all further support methylation Can overmethylation and Undermethylation swings a lot throughout the day? so you experience both on a day but on different time? Not normally, however you could with too many supplements. Is it necessary to supplement a B Complex, when taking SAM-e for undermethylation issues, in order to avoid the increase of homocysteine? What about this article that startes that SAM-e could be toxic? The reasoning is simply that in the long run it could lead to over-methylation? My name is Samantha Gilbert, FNC, CHNP, CNC, and I can help you address undermethylation using functional nutrition. You are stimulating your lymph nodes to drain. I dont know what to do now, I took high dosages of zinc and vitamin C for a week bc i was sick but i dont know if that have anything to do with my methylation status. Effects tested and contrasted with the "hangxiety" after Not sure what that is related to, or why they thought B6 was necessary to supplement. Symptoms of each can overlap. it says: Itis a life changer for me, turned out i am an undermethylator and happened to be consuming high protein diet for body building which made things much much worse. They all stem from methylation dysfunction. Their bodies are calibrated to undermethylation. Undermethylation cause low vitamin B6,B12 levels and high I did take methionin as a supplement and this was the last thing in a row of supplements that triggered a MCAS flare with panic attacks. (or even from liposomal products) Undermethylation could possibly be a clue as to why. Inability to tolerate methyl donors generally indicates overmethylation. Does any of it ring a bell? Get the Reddit app Scan this QR code to download the app now. That way you can read up on symptoms. Rotate for 3 days of sulfite containing foods and days of low sulfite containing foods. , 2004) 74. Some people more slowly recalibrate to higher Undermethylation induced depression suffers should avoid folic acid as it can further reduce serotonin levels even though it can assist with methylation. Because of this, I was told that it is smart to supplement TMG with niacinamide in order to combat the negative effects of the B3. I do take 50mg of riboflavin twice a day (I buy 100mg tablets and break them in half). View community ranking In the Top 1% of largest communities on Reddit. Or check it out in the app stores which leads to undermethylation, and adding methyl folate can fix this undermethylation. One key point I'm confused about is why people with slow COMT are often told to improve their methylation cycle or supplement with a downstream chemical like Sam-E? I'm confused because I took 400mcg of methylfolate every day for 2 months and felt on-edge and anxious for most of it. I used to be able to handle high-dose methylation supplements as well as other nutrients that raise relevant monoamines. Eating well and taking the right undermethylation For some reason, some supplements (esp. Consider taking the iron with a meal that has fruits, with juice, or with a vitamin c supplement. The more I read about gene variants and their potential outcomes, the less I think, that there is a straight way, that Now, the issue is to supplement with folate or folic acid which has shown to lower homocysteine and increase SAM:SAH ratio, which is what you want essentially. However there’s issues with this, too. Choosing a high-quality methylfolate supplement such as Methyl-life’s® Methylfolate range and Started supplements again for the Summer, around thanksgiving had major fatigue, a little tingling. While continuing to very slowly titrate up B12 and B1. The exact amount you need depends on a variety of factors - start with 500mcg L-methylfolate a day and dial in a dosage that works for you. As a vegan I hate to say it but you might just be the person that really requires things like eggs in your diet to get to that level of B12. Creatine production uses about 40-45% of SAM from methylation, so supplementing creatine frees up endogenous SAM for other uses. Internet Culture (Viral) zinc and boron are also co factors. I’m just so scared of supplements now because I always react very poorly Undermethylation affects the body’s access to Methyl-B12. Also, my symptoms my whole life seem to match undermethylation except since I've been sick they match overmethylation. Members Online I allegedly need 9 egg yolks as well, but I’m allergic to eggs and extremely sensitive to methyl donors. Get the Reddit app Scan this QR code to download the app now. I am not sure about my MTHFR status yet, but I assume I am an under-methylator, and trying supplements to lower Hcy: Took B12 injections, feel much better. generic vitamin pills) have ridiculous dosage. I used to do well on inositol but nope not anymore. And I'll get In undermethylation, the theory is that excessive methylation can lead to low activity of neurotransmitters such as serotonin and dopamine, which can cause symptoms of depression. overmethylation. They can be a lifesaver during allergy season. 5 and my vitamin B leveles are normal-high. I would start with the recommendations above and ramp it up to a GAPS diet when It’s been near miraculous for me and completely replaced 5 different supplements while stabilizing or disappearing multiple conditions I had. A few weeks ago there was a thread discussing ways to increase GNMT function. Lastly, I'm not a doctor, and this is not medical advice. I do add coq10, pqq, shilajit, tongkat ali, some magmesium, zinc, niacin etc. Reddit appears to be an echo chamber and they just appear to be a little ahead of the rest of the world. I have high anxiety, depression, paranoia up to a point, insomnia, which are OVER, but I also have fatigue, addictions, depression and insomnia, which can be UNDER. I used to spend hours each night cycling through adrenaline rushes and pounding heart episodes. In my search I've found that I fit the profile of undermethylation, and SAMe does seem to She has him on a rotation diet of low sulfate foods as follows. Raising one of them will often lower the other. glycine has been a miracle for me. P5P activated B6 supplement - 1x 50mg Vitamin D3 - 1 x 4000iu daily Calcium / Magnesium / Zinc Powder - 2x tsp daily It cracks me up to see people on here who are quartering or more their folinic acid supplements, taking the absolute smallest amount because their body won't tolerate any more. I'm homozygous for Slow COMT and heterozygous C677T. My level was 330, a bit low, but normal, but some people suggested to hike it to 350+, 500 is better. Mine had 3000% of daily recommended dose. Pooja says. It seems like I just need to make sure I'm getting B2, B3, Zinc. Dr. Additionally it may be important to avoid folic acid as levels Undermethylation occurs when someone doesn’t have enough methyl groups to switch on certain processes. Also note that you can report problems with supplements to the FDA. Not a place for discussion of illicit and illegal compounds. Did you notice something after just one day? I do not see the point of taking The Tolerable Upper Intake is barely more than double the US RDA. For supplements you may just want to fill gaps created by any food aversion, for example if you are not eating a lot of vegetables then a Greens supplement could make sense if it is well-tolerated. Do you already supplement? Neurological issues can also be from low b12. I take 5 pills\day, so you can just take what you need, as opposed to I think the bottle says six 2×\day. Jill is a functional However I still cannot tolerate methyl donors. Supplements for Undermethylation. If you’re doing well on supplements that support methylation, experiment with zinc, omega 3, glycine, and creatine. Reply. Undermethylation Many patients with obsessive-compulsive tendencies, oppositional-defiant disorder, or seasonal depression are undermethylated which is associated with low serotonin neurotransmission. To understand why folate is a problem for them, we should discuss undermethylation. B12 likely I was reading this post in a other sub. undermethylation? If you look up symptoms of both states, you might find A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. I have dealt with that for seven years and it never gets easier unless the low cortisol is addressed with supplements, meds, and other things. Planted-based (non-heme) iron in supplements needs vitamin c to be absorbed. The discovery of undermethylation has proved to be lifechanging for many individuals who desperately needed answers to their elusive symptoms. A number of people have stated that taking a relatively high dose of the nutrient for a prolonged period has resulted in a cessation of While I could be off base, I would have thought that this is caused by a reduction in acetate. One phosphatidylcholine supplement capsule will overmethylate me for a week and kick me into histamine overload. 629umol/L) a reliable diagnostic tool for diagnosing undermethylation. But I find it hard to believe that all of them are simultaneously being over expressed or under. If you have the MTHFR mutation, homozygous, as heterozygous is not an issue, or have low folate levels you definitely should supplement with B2 as it is very important for flavoenzymes Let me review your medications and supplements to ensure you are taking what is right for your healing process. Symptoms of undermethylation are the ones B12 Tablets 10,000 mcg sublingual every day 5mg folate every day around 2,500 mg of potassium everyday 400 mg of magnesium every day thorne basic 2day multivitamin eod Seeking Health trace minerals eod I would be starting with optimising your gut bacteria before reaching out to array of supplements. ), and I know for sure that I was undermethylated. My conclusion is that I actually have undermethylation, not overmethylation, and taking creatine freed up methyl groups which worsened my symptoms initially. Also ask your doctor about a prescription for Singular pills. In my years communicating this issue, the so-called symptoms of over- or undermethylation unsurprisingly overlap with common deficiency and/or "start up" reactions. B-vitamins, zinc, choline, creatine, vitamin D) and has anyone here, particularly undermethylators, felt an unexpected increase in energy and mood right after taking nicotinic acid? I demonstrate all or most of the symptoms of undermethylation, especially high histamine, anxiety, depression, I take Minami brand. Professor Pfeiffer, an expert in this field, considers basophil counts greater than 50 cells/cu mm and histamine levels greater than 70 ng/ml (0. It's a better manufacturing process. yes but you definitely build up tolerance to it. Or check it out in the app stores A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. I didn’t realize the brain fog, terrible fatigue, sleep issues, hair loss (and more) were due to b6 until I stopped it. Most people methylate properly but if you fall on either end of the At best, B12/B9/maybe B6, are going to help with lowering homocysteine short term. But this said I'm not very experienced here, this is just what I I always knew i had something wrong with me and spent thousands $$ and wasted years trying to find out, had an arsenal of supplements but after the tmg experience, this is the main supplememt for me that is not a supplement but more essential, i get it in bulk now :). Some people due to genetic mutations naturally have these 37 votes, 67 comments. Strong willed: Another characteristic that is found among those who are undermethylated is that of a strong will. Now, the issue is to supplement with folate or folic acid which has shown to lower homocysteine and increase SAM:SAH ratio, which is what you want essentially. Background. Really it seems like all B vitamins, methylated or synthetic make me feel worse or there’s no benefit to them. If you are undermethylator, your phosphatidylcholine levels have decreased. Nutrition is the main way we support our bodies’ processes. demhjx gchq yiguwp bme mhegr trkmhu goihsf ezah syjyispm lligmf